Pub. Date : 2020 Feb
PMID : 32096202
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin reduced the ROS, MDA, 4-HNE, and 8-OHdG contents but further enhanced the levels of the nuclear factor E2-related factor-2 (Nrf2) and heme oxygenase (HO-1). | Melatonin | heme oxygenase 1 | Homo sapiens |
| 2 | Melatonin-increased viability and melatonin-decreased LDH release were also mediated by the blockage of NF-kappaB or reversed by Nrf2 or HO-1 knockdown. | Melatonin | heme oxygenase 1 | Homo sapiens |
| 3 | Melatonin-increased viability and melatonin-decreased LDH release were also mediated by the blockage of NF-kappaB or reversed by Nrf2 or HO-1 knockdown. | Melatonin | heme oxygenase 1 | Homo sapiens |
| 4 | CONCLUSIONS: Melatonin protected SH SY5Y cells from OGD/R induced oxidative stress, inflammation, apoptosis, and autophagy by blocking NF-kappaB signaling and activating Nrf2/HO-1, Akt, and mTOR/p70S6K/4E-BP-1 pathways, thereby indicating that melatonin is a potential and novel therapeutic drug for ischemic stroke. | Melatonin | heme oxygenase 1 | Homo sapiens |