Title : Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro-β-erythroidine in nicotine-tolerant mice.

Pub. Date : 2020 Apr

PMID : 32092237






3 Functional Relationships(s)
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1 Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro-beta-erythroidine in nicotine-tolerant mice. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 OBJECTIVES: There is a long-standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 Previous studies demonstrate that daily nicotine treatment confers tolerance to some effects of nicotine, as well as cross-tolerance to other nAChR agonists. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus