Title : Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.

Pub. Date : 2020 May

PMID : 32088264






4 Functional Relationships(s)
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1 Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Serotonin 5-hydroxytryptamine receptor 1B Homo sapiens
2 The 5-HT1A and 5-HT1B serotonin receptors are abundantly expressed in the CNS and constitute validated as well as putative drug targets in a variety of psychiatric and cognitive disorders, alcoholism/addiction, pain and migraine. Serotonin 5-hydroxytryptamine receptor 1B Homo sapiens
3 Serotonin and other agonists induced robust decreases in fluorescence levels in the 5-HT1A/GIRK2- and 5-HT1B/GIRK2-HEK293 cells in a concentration-dependent manner in the assay, and these responses could be inhibited by selective 5-HT1A/5-HT1B antagonists and by the Galphai/o-protein inhibitor pertussis toxin (PTX). Serotonin 5-hydroxytryptamine receptor 1B Homo sapiens
4 Serotonin and other agonists induced robust decreases in fluorescence levels in the 5-HT1A/GIRK2- and 5-HT1B/GIRK2-HEK293 cells in a concentration-dependent manner in the assay, and these responses could be inhibited by selective 5-HT1A/5-HT1B antagonists and by the Galphai/o-protein inhibitor pertussis toxin (PTX). Serotonin 5-hydroxytryptamine receptor 1B Homo sapiens