Title : The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells.

Pub. Date : 2020 Jun

PMID : 32087304






1 Functional Relationships(s)
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1 Collectively, our data demonstrate that lenvatinib and entinostat interact to kill liver cancer cells via ROS-dependent activation of ATM and inactivation of eIF2alpha, resulting in greater levels of toxic autophagosome formation and reduced expression of protective mitochondrial proteins. lenvatinib eukaryotic translation initiation factor 2A Homo sapiens