Title : Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa.

Pub. Date : 2020 Jun 1

PMID : 32083659






3 Functional Relationships(s)
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1 METHODS: Pseudomonal PBP-binding affinities of cefepime, zidebactam and imipenem were assessed at different timepoints and also in the presence of purified VIM-1 using a Bocillin FL competition assay. Cefepime dedicator of cyto-kinesis 3 Mus musculus
2 Finally, complementary PBP inhibition by cefepime/zidebactam resulted in enhanced bactericidal activity in time-kill and neutropenic mouse lung/thigh infection studies against VIM-6-, VIM-10- and VIM-11-expressing P. aeruginosa, thus revealing the mechanistic basis of beta-lactam enhancer action. Cefepime dedicator of cyto-kinesis 3 Mus musculus
3 For cefepime, this seems to be a result of a faster rate of PBP binding, which helps it overcome beta-lactamase-mediated hydrolysis. Cefepime dedicator of cyto-kinesis 3 Mus musculus