Title : Targeting MDR-1 gene expression, BAX/BCL2, caspase-3, and Ki-67 by nanoencapsulated imatinib and hesperidin to enhance anticancer activity and ameliorate cardiotoxicity.

Pub. Date : 2020 Aug

PMID : 32080901






2 Functional Relationships(s)
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1 Targeting MDR-1 gene expression, BAX/BCL2, caspase-3 and Ki-67 by nano-encapsulated imatinib and hesperidin to enhance anticancer activity and ameliorate cardiotoxicity. Hesperidin malic enzyme complex, mitochondrial Mus musculus
2 Nano IM and/or Nano HES treated groups showed a significant reduction in tumor volume, weight, hematological, cardiac markers and tumor MDR-1 gene down regulation compared to free conventional treated groups. Hesperidin malic enzyme complex, mitochondrial Mus musculus