Title : Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.

Pub. Date : 2020 Mar 15

PMID : 32078860






1 Functional Relationships(s)
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1 Here, we identified two small molecules, SBC040 and SBC219, which are two efficient cAMP-independent potentiators, acting at low concentration of forskolin with EC50 close to 1 muM and in a synergic way with the drug VX-770 on several CFTR mutants of classes II and III. Colforsin CF transmembrane conductance regulator Homo sapiens