Title : Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.

Pub. Date : 2020 Feb 19

PMID : 32076068






3 Functional Relationships(s)
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1 Particularly, the expression of tumour-suppressing gene Ccdc80 was induced by vactosertib and further induced by vactosertib in combination with nal-IRI/5-FU/LV. vactosertib coiled-coil domain containing 80 Mus musculus
2 Particularly, the expression of tumour-suppressing gene Ccdc80 was induced by vactosertib and further induced by vactosertib in combination with nal-IRI/5-FU/LV. vactosertib coiled-coil domain containing 80 Mus musculus
3 Collectively, these results indicate that combination treatment of vactosertib with nal-IRI/5-FU/LV improves overall survival rates in a mouse model of pancreatic cancer by suppressing invasion through CCDC80. vactosertib coiled-coil domain containing 80 Mus musculus