Title : One-carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects?

Pub. Date : 2020 Jun

PMID : 32061804






2 Functional Relationships(s)
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1 Folic acid supplementation has been shown to prevent the occurrence of NTDs by as much as 70% in some human populations, and folate deficiency in a pregnant woman is associated with increased risk for having an NTD affected infant. Folic Acid fuzzy planar cell polarity protein Homo sapiens
2 Herein, we review the genes involved in folate transport and one carbon metabolism thus far identified as contributing variants that influence human NTD risk, and place these findings in the context of our evolving understanding of the complex genetic architecture underlying these defects. Folic Acid fuzzy planar cell polarity protein Homo sapiens