Title : Decreasing Arl4c expression by inhibition of AKT signal in human lung adenocarcinoma cells.

Pub. Date : 2020 Apr 1

PMID : 32057901






5 Functional Relationships(s)
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1 Finally, we found that chemotherapy drug hydroxycamptothecin (HCPT) could decrease Arl4c expression levels by inhibiting the activation of the AKT pathway in A549 and 95-D cells. 10-hydroxycamptothecin ADP ribosylation factor like GTPase 4C Homo sapiens
2 Finally, we found that chemotherapy drug hydroxycamptothecin (HCPT) could decrease Arl4c expression levels by inhibiting the activation of the AKT pathway in A549 and 95-D cells. 10-hydroxycamptothecin ADP ribosylation factor like GTPase 4C Homo sapiens
3 Moreover, accumulation of ubiquitinated Arl4c protein was increased by HCPT and LY294002 (an AKT inhibitor) treatment whereas the proteasome inhibitor MG-132 attenuated the inhibitory effect of HCPT and LY294002 on Arl4c expression. 10-hydroxycamptothecin ADP ribosylation factor like GTPase 4C Homo sapiens
4 CONCLUSION: Here, we highlighted the AKT pathway as an important regulatory pathway for Arl4c expression in lung cancer cells and identified HCPT as a promising drug for lung adenocarcinoma treatment that functioned by targeting Arl4c expression. 10-hydroxycamptothecin ADP ribosylation factor like GTPase 4C Homo sapiens
5 CONCLUSION: Here, we highlighted the AKT pathway as an important regulatory pathway for Arl4c expression in lung cancer cells and identified HCPT as a promising drug for lung adenocarcinoma treatment that functioned by targeting Arl4c expression. 10-hydroxycamptothecin ADP ribosylation factor like GTPase 4C Homo sapiens