Title : GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1.

Pub. Date : 2020

PMID : 32053631






1 Functional Relationships(s)
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1 More generally, dermal, cardiac and lung fibroblast responses to TGFbeta1 could be enhanced by increasing YAP nuclear levels (with GPCR ligands LPA, S1P, thrombin or Rho activator) and inhibited by decreasing nuclear YAP (with Rho inhibitor, forskolin, latrunculin B or 2-deoxy-glucose). Colforsin transforming growth factor beta 1 Homo sapiens