Title : TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells.

Pub. Date : 2020

PMID : 32049985






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. Iodides solute carrier family 5 member 5 Homo sapiens
2 Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to malignant transformation. Iodides solute carrier family 5 member 5 Homo sapiens
3 Additionally, TNF-alpha and PMA were shown to have a negative impact on TSH-induced iodide uptake, consistent with the observed transcriptional downregulation of NIS. Iodides solute carrier family 5 member 5 Homo sapiens
4 A better understanding of the mechanisms underlying NIS expression in the context of normal thyroid physiology may guide the development of pharmacological strategies to increase the efficiency of iodide uptake. Iodides solute carrier family 5 member 5 Homo sapiens