Pub. Date : 2020
PMID : 32049985
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. | Iodides | solute carrier family 5 member 5 | Homo sapiens |
| 2 | Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to malignant transformation. | Iodides | solute carrier family 5 member 5 | Homo sapiens |
| 3 | Additionally, TNF-alpha and PMA were shown to have a negative impact on TSH-induced iodide uptake, consistent with the observed transcriptional downregulation of NIS. | Iodides | solute carrier family 5 member 5 | Homo sapiens |
| 4 | A better understanding of the mechanisms underlying NIS expression in the context of normal thyroid physiology may guide the development of pharmacological strategies to increase the efficiency of iodide uptake. | Iodides | solute carrier family 5 member 5 | Homo sapiens |