Title : Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1.

Pub. Date : 2020 Feb 5

PMID : 32039693






1 Functional Relationships(s)
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1 These results indicate that a Cap-induced decrease in the LV contractility, like in cases of hyperthermia, are due to the down-regulation of the total calcium handling in E-C coupling, suggesting that negative inotropic effect in hyperthermia-heart is, at least in part, mediated through TRPV1 signaling pathway. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus