Pub. Date : 2020 Mar
PMID : 32032848
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | When tested in vitro in a colorimetric assay for their ability to inhibit AChE, the new compounds showed higher or similar potency compared to that of tacrine. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The results were compared with those obtained on the known derivatives 6-C7 and 6-C10, two quite potent AChE inhibitors in which tacrine is linked to iperoxo, an exceptionally potent muscarinic orthosteric activator. | Tacrine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |