Title : Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors.

Pub. Date : 2020 Mar

PMID : 32032848






1 Functional Relationships(s)
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1 The results were compared with those obtained on the known derivatives 6-C7 and 6-C10, two quite potent AChE inhibitors in which tacrine is linked to iperoxo, an exceptionally potent muscarinic orthosteric activator. 6-c7 acetylcholinesterase (Cartwright blood group) Homo sapiens