Title : Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

Pub. Date : 2020 May

PMID : 32032660






2 Functional Relationships(s)
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1 Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. Nitrogen tumor protein p53 Homo sapiens
2 Moreover, cells exposed to A + N can influence neighboring cells in paracrine fashion, for instance, they shed ectodomain of COL17A1 protein and induce, in p53-dependent mode, the expression of gene for interleukin-7. Nitrogen tumor protein p53 Homo sapiens