Title : In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines.

Pub. Date : 1988 Jul

PMID : 3203057






1 Functional Relationships(s)
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1 Although the competitive inhibition between some sulphonamides and tolbutamide is consistent with metabolism by the same isozyme of cytochrome P-450 it does not prove it and further studies with purified enzymes will be necessary to confirm this. Tolbutamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens