Pub. Date : 2020 Apr 6
PMID : 32022567
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specific binding to HER2 and/or EGFR was assessed by incubating BC cells with DRT AuNP-177Lu or TmAb-AuNP-177Lu or PmAb-AuNP-177Lu or NT-AuNP-177Lu in the absence or presence of an excess of TmAb or PmAb or both competitors. | Gold | epidermal growth factor receptor | Homo sapiens |
| 2 | Specific binding to HER2 and/or EGFR was assessed by incubating BC cells with DRT AuNP-177Lu or TmAb-AuNP-177Lu or PmAb-AuNP-177Lu or NT-AuNP-177Lu in the absence or presence of an excess of TmAb or PmAb or both competitors. | Gold | epidermal growth factor receptor | Homo sapiens |
| 3 | Specific binding to HER2 and/or EGFR was assessed by incubating BC cells with DRT AuNP-177Lu or TmAb-AuNP-177Lu or PmAb-AuNP-177Lu or NT-AuNP-177Lu in the absence or presence of an excess of TmAb or PmAb or both competitors. | Gold | epidermal growth factor receptor | Homo sapiens |
| 4 | Specific binding to HER2 and/or EGFR was assessed by incubating BC cells with DRT AuNP-177Lu or TmAb-AuNP-177Lu or PmAb-AuNP-177Lu or NT-AuNP-177Lu in the absence or presence of an excess of TmAb or PmAb or both competitors. | Gold | epidermal growth factor receptor | Homo sapiens |
| 5 | DRT AuNP-177Lu were specifically bound by BC cells that expressed HER2 or EGFR or both receptors. | Gold | epidermal growth factor receptor | Homo sapiens |
| 6 | In contrast, SRT TmAb-AuNP-177Lu and PmAb-AuNP-177Lu were bound and internalized only by BC cells that expressed HER2 or EGFR, respectively. | Gold | epidermal growth factor receptor | Homo sapiens |
| 7 | Importantly, DRT AuNP-177Lu were more potent in vitro than PmAb-AuNP-177Lu for killing MDA-MB-231-H2N cells that co-express HER2 and EGFR (CS= 18.8 +- 1.0% vs. 51.5 +- 10.4%; P=0.006). | Gold | epidermal growth factor receptor | Homo sapiens |
| 8 | Furthermore, DRT AuNP-177Lu were more potent for killing BT-474 cells with high HER2 but low EGFR expression than TmAb-AuNP-177Lu (CS= 8.9 +- 3.3% vs. 20.7 +- 2.4%; P=0.007) or PmAb-AuNP-177Lu (CS=63.9 +- 1.7%; P<0.0001). | Gold | epidermal growth factor receptor | Homo sapiens |