Pub. Date : 2020
PMID : 32021384
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Purpose: This study was conducted to determine the effect of UGT1A9 98T>C, CYP2B6 516G>T and CYP2C9 430C>T genetic polymorphisms on the pharmacokinetics of propofol in children of different sexes and ages who undergone total intravenous anesthesia (TIVA) and deep sedation during diagnostic and therapeutic procedures. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The carriers of the polymorphic CYP2B6 T allele received a significantly lower overall and initial dose of propofol. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Conclusion: Further investigations of UGT1A9, CYP2B6 and CYP2C9 and other genes that participate in propofol metabolism as well as detailed analyses of the general conditions, administered therapies and associated diseases could explain the large interindividual variability of propofol metabolism in children. | Propofol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |