Title : Suppression of DRP1‑mediated mitophagy increases the apoptosis of hepatocellular carcinoma cells in the setting of chemotherapy.

Pub. Date : 2020 Mar

PMID : 32020220






3 Functional Relationships(s)
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1 Accordingly, cisplatin induced mitophagy in surviving HCC cells by activating DRP1. Cisplatin dynamin 1 like Homo sapiens
2 The DRP1 inhibitor (Mdivi-1) increased the apoptosis of cisplatin-treated HCC cells by targeting mitophagy. Cisplatin dynamin 1 like Homo sapiens
3 Our results indicate that targeting cisplatin-mediated mitophagy increases HCC apoptosis via DRP1 inhibition, providing preclinical proof of concept for combination therapy targeting mitophagy to potentiate the efficacy of chemotherapy. Cisplatin dynamin 1 like Homo sapiens