Title : Assessment of Risk for Interference by Circulating Biotin in Samples Received for High Sensitivity Troponin-T, Thyrotropin, and for Prostate Specific Antigen Testing by Immunoassays.

Pub. Date : 2020 Jan 1

PMID : 32013345






3 Functional Relationships(s)
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1 Circulating biotin levels greater than 20 ng/mL are reported to exhibit interference in high sensitivity troponin T (hs-TnT), thyroid stimulating hormone (TSH), and in prostate specific antigen (PSA) among other assays when using our Cobas 6000 immunoassay analyzer (Roche Diagnostics, IN, USA). Biotin kallikrein related peptidase 3 Homo sapiens
2 Circulating biotin levels greater than 20 ng/mL are reported to exhibit interference in high sensitivity troponin T (hs-TnT), thyroid stimulating hormone (TSH), and in prostate specific antigen (PSA) among other assays when using our Cobas 6000 immunoassay analyzer (Roche Diagnostics, IN, USA). Biotin kallikrein related peptidase 3 Homo sapiens
3 The median and (range) biotin concentrations in hs-TnT, TSH, and PSA samples were 0.27 ng/mL (0.02 - 6.86 ng/mL), 0.39 ng/mL (0.08 - 11.38 ng/mL), and 0.47 ng/mL (0.09 - 7.73 ng/mL), respectively. Biotin kallikrein related peptidase 3 Homo sapiens