Title : WNT/β-catenin signal inhibitor IC-2-derived small-molecule compounds suppress TGF-β1-induced fibrogenic response of renal epithelial cells by inhibiting SMAD2/3 signalling.

Pub. Date : 2020 Jun

PMID : 32012313






1 Functional Relationships(s)
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1 All these compounds inhibited LiCl-induced WNT/beta-catenin reporter activation to a similar extent, whereas ICG-001, IC-2-OTBS, and IC-2-F almost completely suppressed TGF-beta1-induced SMAD reporter activation without apparent cytotoxicity. Lithium Chloride transforming growth factor beta 1 Homo sapiens