Pub. Date : 2020 Feb
PMID : 32012242
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H2 O2 induces oxidative stress damage through the BMP-6/SMAD/hepcidin axis. | Hydrogen Peroxide | bone morphogenetic protein 6 | Homo sapiens |
| 2 | Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 . | Hydrogen Peroxide | bone morphogenetic protein 6 | Homo sapiens |
| 3 | Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 . | Hydrogen Peroxide | bone morphogenetic protein 6 | Homo sapiens |
| 4 | Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 . | Hydrogen Peroxide | bone morphogenetic protein 6 | Homo sapiens |
| 5 | Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 . | Hydrogen Peroxide | bone morphogenetic protein 6 | Homo sapiens |
| 6 | In addition, alterations in smad1 and smad5 expression were examined, and pretreatment with BMP-6 was demonstrated to reduce H2 O2 -induced activation of smad1 and smad5. | Hydrogen Peroxide | bone morphogenetic protein 6 | Homo sapiens |