Title : Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel.

Pub. Date : 1988 Dec

PMID : 3200857






1 Functional Relationships(s)
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1 Results of studies of hypophysectomized rats suggest that growth hormone serves as a final common mediator through which gonadal steroids and other modifiers of pituitary function alter the expression of gender-specific liver genes such as the sexually dimorphic pair of cytochrome P-450 isozymes, male-specific P-450h and female-specific P-450i. Steroids cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus