Title : Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.

Pub. Date : 2020 Apr 6

PMID : 31999304






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cbl-b binds to the K63-ubiquitin chains attached to the NLRP3 leucine-rich repeat domain (LRR) via its ubiquitin-associated region (UBA) and then targets NLRP3 at K496 for K48-linked ubiquitination and proteasome-mediated degradation. Leucine NLR family pyrin domain containing 3 Homo sapiens