Title : Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.

Pub. Date : 2020 Feb

PMID : 31993732






1 Functional Relationships(s)
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1 Selegiline and rasagiline, inhibitors of type B monoamine oxidase, have been proved to exhibit potent neuroprotective function: regulation of mitochondrial apoptosis system, maintenance of mitochondrial function, increased expression of genes coding antioxidant enzymes, anti-apoptotic Bcl-2 and pro-survival NTFs, and suppression of oligomerization and aggregation of alpha-synuclein and the toxicity in cellular and animal experiments. rasagiline BCL2 apoptosis regulator Homo sapiens