Pub. Date : 2020 Mar
PMID : 31993509
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study examined the effects of microtubule-targeting anticancer drugs (paclitaxel, cabazitaxel, and eribulin) on the expression of drug efflux transporter P-glycoprotein, which is encoded by MDR1. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | This study examined the effects of microtubule-targeting anticancer drugs (paclitaxel, cabazitaxel, and eribulin) on the expression of drug efflux transporter P-glycoprotein, which is encoded by MDR1. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Paclitaxel and eribulin induced MDR1 promoter activity in a concentration-dependent manner, while cabazitaxel had little effect in human intestinal epithelial LS174T cells. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Overexpression of the nuclear receptor pregnane X receptor (PXR) gene (NR1I2) enhanced paclitaxel- and eribulin-induced MDR1 activation, but expression of the nuclear receptor co-repressor silencing mediator for retinoid and thyroid receptors (SMRT) gene (NCOR2) repressed MDR1 activation. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Cellular uptake of rhodamine 123 and calcein-acetoxymethyl ester (calcein-AM), P-glycoprotein substrates, decreased in paclitaxel- or eribulin-treated LS174T cells. | Paclitaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |