Pub. Date : 2020 Jan 24
PMID : 31991669
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Both CURC-loaded SLNs were 5-10-fold more effective than free CURC in increasing the intracellular retention and toxicity of doxorubicin in Pgp-expressing triple negative breast cancer (TNBC). | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | These results suggest that the combination therapy, based on CURC-loaded SLNs and doxorubicin, is an effective and safe approach to overcome the Pgp-mediated chemoresistance in TNBC. | Curcumin | ATP binding cassette subfamily B member 1 | Homo sapiens |