Title : Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression.

Pub. Date : 2020 Mar

PMID : 31985018






3 Functional Relationships(s)
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1 The western blot analysis data suggested that ICI 182780, which causes estrogen receptor alpha (ERalpha) degradation, reversed the icaritin-induced decrease in SOST expression, which was inconsistent with the results of immunofluorescence analysis. icaritin estrogen receptor 1 Homo sapiens
2 The western blot analysis data suggested that ICI 182780, which causes estrogen receptor alpha (ERalpha) degradation, reversed the icaritin-induced decrease in SOST expression, which was inconsistent with the results of immunofluorescence analysis. icaritin estrogen receptor 1 Homo sapiens
3 In conclusion, icaritin was demonstrated to promote the osteogenesis of hBMSCs by downregulating SOST expression, and icaritin-induced suppression of SOST was regulated in part via the Wnt/beta-catenin/ERalpha axis. icaritin estrogen receptor 1 Homo sapiens