Title : ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease.

Pub. Date : 2020 Mar

PMID : 31982938






2 Functional Relationships(s)
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1 We now show that enhancement of brain ACE2 activity, a major effector of rRAS, by intraperitoneal administration of diminazene aceturate (DIZE), an established activator of ACE2, lowered hippocampal Abeta and restored cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice. diminazene aceturate amyloid beta (A4) precursor protein Mus musculus
2 We now show that enhancement of brain ACE2 activity, a major effector of rRAS, by intraperitoneal administration of diminazene aceturate (DIZE), an established activator of ACE2, lowered hippocampal Abeta and restored cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice. diminazene aceturate amyloid beta (A4) precursor protein Mus musculus