Title : Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease.

Pub. Date : 2020 Mar

PMID : 31978679






1 Functional Relationships(s)
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Protein Name
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1 Compounds 4ah and 4bh proved to be more potent than the standard drug tacrine, rivastigmine and galantamine for AChE inhibition activity with IC50 value between 0.055 +- 0.143 microM and 0.017 +- 0.02 microM respectively. Rivastigmine acetylcholinesterase (Cartwright blood group) Homo sapiens