Title : P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK.

Pub. Date : 2020 Mar 19

PMID : 31973815






5 Functional Relationships(s)
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1 Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels. Tetradecanoylphorbol Acetate ras homolog family member A Homo sapiens
2 Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels. Tetradecanoylphorbol Acetate ras homolog family member A Homo sapiens
3 Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels. Tetradecanoylphorbol Acetate ras homolog family member A Homo sapiens
4 In exploring the mechanism of PMA effects, we reduced RhoA levels in test cells with si-RhoA and then restoration of various versions of RhoA for effect in response of the cells to PMA and producing superoxides. Tetradecanoylphorbol Acetate ras homolog family member A Homo sapiens
5 Restoration of RhoA Y42F (a dephospho-mimic form) still had reduced superoxide formation in response to PMA, compared with WT and Y42E RhoA. Tetradecanoylphorbol Acetate ras homolog family member A Homo sapiens