Pub. Date : 2020 May
PMID : 31970864
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expansion above a certain threshold in the polyglutamine (polyQ) tract of ataxin-3 is the main cause of neurodegeneration in Machado-Joseph disease. | polyglutamine | ataxin 3 | Homo sapiens |
| 2 | Expansion above a certain threshold in the polyglutamine (polyQ) tract of ataxin-3 is the main cause of neurodegeneration in Machado-Joseph disease. | polyglutamine | ataxin 3 | Homo sapiens |
| 3 | Ataxin-3 contains an N-terminal catalytic domain, called Josephin domain, and a highly aggregation-prone C-terminal domain containing the polyQ tract. | polyglutamine | ataxin 3 | Homo sapiens |
| 4 | We hypothesize that the expansion of the polyQ tract in ataxin-3 could impact CME. | polyglutamine | ataxin 3 | Homo sapiens |