Title : Design, Synthesis, and In Vitro Evaluation of the Photoactivatable Prodrug of the PARP Inhibitor Talazoparib.

Pub. Date : 2020 Jan 18

PMID : 31963730






1 Functional Relationships(s)
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1 A PARP-1 enzyme inhibition assay and PARylation experiment showed that the inhibitory activity of the prodrug was reduced 380 times and more than 658 times, respectively, which proved that the prodrug"s expected activity was lost after PPG protection. ppg poly(ADP-ribose) polymerase 1 Homo sapiens