Title : Involvement of phospholipase A2 in the regulation of [3H]hemicholinium-3 binding.

Pub. Date : 1988 Nov 15

PMID : 3196359






3 Functional Relationships(s)
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1 Incubation of striatal synaptic membranes with bee venom PLA2 resulted in a concentration-dependent increase in the specific binding of [3H]HCh-3. alpha-hexachlorocyclohexane phospholipase A2 group IB Homo sapiens
2 However, higher concentrations of PLA2, which further increased the specific binding of [3H]HCh-3, caused a reduction of [3H]choline uptake, apparently due to disruption of synaptosomal integrity by PLA2. alpha-hexachlorocyclohexane phospholipase A2 group IB Homo sapiens
3 Finally, potassium depolarization- and PLA2-induced increases in specific [3H]HCh-3 binding were not additive. alpha-hexachlorocyclohexane phospholipase A2 group IB Homo sapiens