Title : Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.

Pub. Date : 2020 Jan 16

PMID : 31945013






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1 METHODS: The effects of metformin on cartilage degradation and chondrocyte aging was determined in a destabilization of the medial meniscus (DMM)-induced OA mouse model and in IL-1beta-treated mouse chondrocytes and cartilage explants. Metformin interleukin 1 beta Mus musculus