Title : Synthesis and Biological Characterization of Monomeric and Tetrameric RGD-Cryptophycin Conjugates.

Pub. Date : 2020 Feb 26

PMID : 31943410






1 Functional Relationships(s)
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1 Herein, we report the synthesis and biological evaluation of a multimeric conjugate containing the high-affinity integrin alphav beta3 binding ligand RAFT-c(RGDfK)4 , a lysosomally cleavable Val-Cit linker, and cryptophycin-55 glycinate, a potent inhibitor of tubulin polymerization. cryptophycin integrin subunit alpha V Homo sapiens