Title : Novel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile.

Pub. Date : 2020 Jun

PMID : 31943295






2 Functional Relationships(s)
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1 The bromo-substituted coumarins 3a and 3b were remarkably active against HeLa cell line showing IC50 1.8 and 6.1 muM, respectively. coumarin latexin Homo sapiens
2 Coumarin 5e possessing a geranyloxy-chain on position 5 of the coumarin scaffold presented dual bioactivity, while 5-geranyloxy-coumarin 5f was the most competent soybean lipoxygenase inhibitor of this series (IC50 10 muM). coumarin latexin Homo sapiens