Title : BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis.

Pub. Date : 2020 Jan 13

PMID : 31931832






2 Functional Relationships(s)
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1 Besides, the intrathecal injection of exogenous BDNF further decreased the mechanical withdrawal threshold, promoted activation of astrocytes and microglia, and increased the release of TNF-alpha and IL-1beta in the SDH of our CYP-induced cystitis model. Cyclophosphamide tumor necrosis factor Homo sapiens
2 CONCLUSIONS: In our CYP-induced cystitis model, BDNF promoted the activation of astrocytes and microglia to release TNF-alpha and IL-1beta, aggravating neuroinflammation and leading to mechanical allodynia through BDNF-TrkB-p38/JNK signaling. Cyclophosphamide tumor necrosis factor Homo sapiens