Title : Beta-Cell-Specific Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 Aggravates High-Fat Diet-Induced Impairment of Islet Insulin Secretion in Mice.

Pub. Date : 2020 Mar 20

PMID : 31931619






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In cultures of dispersed islets NOX5 protein was observed in somatostatin-positive (delta) cells in basal (2.8mM glucose) conditions. Glucose NADPH oxidase 5 Homo sapiens
2 siRNA-mediated knock-down of NOX5 in human islets cultured in basal glucose concentrations resulted in diminished glucose-induced insulin secretion in vitro. Glucose NADPH oxidase 5 Homo sapiens
3 siRNA-mediated knock-down of NOX5 in human islets cultured in basal glucose concentrations resulted in diminished glucose-induced insulin secretion in vitro. Glucose NADPH oxidase 5 Homo sapiens
4 However, when islets were preincubated in high (16.7mM) glucose media for 12 hours, NOX5 appeared also in insulin-positive (beta) cells. Glucose NADPH oxidase 5 Homo sapiens
5 In vivo, mice with beta-cell NOX5 expression developed aggravated impairment of glucose-induced insulin secretion compared to control mice when challenged with 14 weeks of high-fat diet. Glucose NADPH oxidase 5 Homo sapiens