Title : Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension.

Pub. Date : 2020 Mar

PMID : 31931441






1 Functional Relationships(s)
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1 Oral gavage of monocrotaline-induced PAH rats resulted in dose-dependent delivery of ANG-(1-7) and ACE2 in plasma/tissues and PAH development was attenuated with decreases in right ventricular (RV) hypertrophy, RV systolic pressure, total pulmonary resistance and pulmonary artery remodeling. Monocrotaline angiotensin I converting enzyme 2 Rattus norvegicus