Title : Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine.

Pub. Date : 2020 Apr

PMID : 31929398






1 Functional Relationships(s)
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1 The AUC ratios of norbuprenorphine and norbuprenorphine glucuronide to buprenorphine, a measure of CYP3A mediated N-demethylation, were 1.89, 1.84, and 1.33 during the 1 and 2, 3 trimesters, and postpartum, respectively. Nitrogen cytochrome P450 family 3 subfamily A member 4 Homo sapiens