Title : The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.

Pub. Date : 2020 Nov

PMID : 31925452






4 Functional Relationships(s)
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1 Thus, CB1 antagonists such as SR141716A, also known as rimonabant, and AM251 act as GPR55 agonists in some cell types. Rimonabant G protein-coupled receptor 55 Homo sapiens
2 Thus, CB1 antagonists such as SR141716A, also known as rimonabant, and AM251 act as GPR55 agonists in some cell types. Rimonabant G protein-coupled receptor 55 Homo sapiens
3 The complex pharmacological properties of cannabinoids make it difficult to fully identify the relative importance of CB1 and GPR55 in the functional effects of SR141716A, and AM251. Rimonabant G protein-coupled receptor 55 Homo sapiens
4 Here, we determine whether SR141716A and AM251 regulation of mouse and human islet function is through their action as GPR55 agonists. Rimonabant G protein-coupled receptor 55 Homo sapiens