Pub. Date : 2020 Mar
PMID : 31924695
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ser100-Phosphorylated RORalpha Orchestrates CAR and HNF4alpha to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Here, we found serine 100-phosphorylated RORalpha orchestrates constitutive androstane receptor (CAR) and hepatocyte nuclear factor 4 alpha (HNF4alpha) to induce CYP2B6 by phenobarbital (PB) in human primary hepatocytes (HPHs). | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Here, we found serine 100-phosphorylated RORalpha orchestrates constitutive androstane receptor (CAR) and hepatocyte nuclear factor 4 alpha (HNF4alpha) to induce CYP2B6 by phenobarbital (PB) in human primary hepatocytes (HPHs). | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Altogether, the results established that p-Ser100 RORalpha bridging the PBREM and OARE orchestrates CAR and HNF4alpha to form active chromatin complex during PB-induced CYP2B6 expression in human primary hepatocytes. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | SIGNIFICANCE STATEMENT: CYP2B6 is a vital enzyme for the metabolic elimination of xenobiotics, and it is prone to induction by xenobiotics, including phenobarbital via constitutive androstane receptor (CAR) and hepatocyte nuclear factor 4 alpha (HNF4alpha). | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |