Pub. Date : 2020 Mar
PMID : 31923941
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For the first time, MDM2-mediated p53 degradation was identified as a critical factor for developing acquired resistance of doxorubicin (DOX) in HepG2 tumor spheroids, which could be effectively reversed by MDM2 inhibitor MI-773, thereby improving anticancer effects. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 2 | For the first time, MDM2-mediated p53 degradation was identified as a critical factor for developing acquired resistance of doxorubicin (DOX) in HepG2 tumor spheroids, which could be effectively reversed by MDM2 inhibitor MI-773, thereby improving anticancer effects. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 3 | Therefore, a pH-sensitive liposomal formulation of DOX and MI-773 (LipD/M@CMCS) were developed for recovering p53-mediated DOX resistance in hepatocellular carcinoma. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 4 | Therefore, a pH-sensitive liposomal formulation of DOX and MI-773 (LipD/M@CMCS) were developed for recovering p53-mediated DOX resistance in hepatocellular carcinoma. | Doxorubicin | tumor protein p53 | Homo sapiens |