Title : Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors.

Pub. Date : 2020 Jan

PMID : 31915112






1 Functional Relationships(s)
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1 In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85 muM for CA IX/XII). Hydroxamic Acids carbonic anhydrase 3 Homo sapiens