Title : PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression.

Pub. Date : 2020 Feb 1

PMID : 31913463






2 Functional Relationships(s)
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1 We show here that retinoic acid signaling is active during pituitary organogenesis and dependent on the pituitary transcription factor Prop1.Prop1-mutant mice show reduced expression of the aldehyde dehydrogenase gene Aldh1a2, which metabolizes the vitamin A-intermediate retinaldehyde into retinoic acid. Tretinoin aldehyde dehydrogenase family 1, subfamily A2 Mus musculus
2 We show here that retinoic acid signaling is active during pituitary organogenesis and dependent on the pituitary transcription factor Prop1.Prop1-mutant mice show reduced expression of the aldehyde dehydrogenase gene Aldh1a2, which metabolizes the vitamin A-intermediate retinaldehyde into retinoic acid. Tretinoin aldehyde dehydrogenase family 1, subfamily A2 Mus musculus