Pub. Date : 2019
PMID : 31908475
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study aimed to explore whether lncRNA NCK-AS1 could affect the cisplatin (DDP) resistance in human osteosarcoma cell and the underlying molecular mechanism. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | prostaglandin D2 receptor | Homo sapiens |
| 2 | Results: The results revealed that NCK1-AS1 was significantly upregulated in osteosarcoma cells, as well as in DDP-resistant osteosarcoma cells. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | prostaglandin D2 receptor | Homo sapiens |
| 3 | NCK1-AS1 silence inhibited the proliferation, migration and invasion of osteosarcoma cells, whereas enhanced the sensitivity of osteosarcoma cells to DDP. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | prostaglandin D2 receptor | Homo sapiens |
| 4 | Most importantly, miR-137 overexpression enhanced the sensitivity of osteosarcoma cells to DDP, and high expression of NCK1-AS1 reversed the influences of miR-137 overexpression on DDP-resistant cells. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | prostaglandin D2 receptor | Homo sapiens |
| 5 | Conclusion: In short, NCK1-AS1 knockdown enhanced DDP sensitivity of osteosarcoma cells by regulating miR-137, which may be a novel potential target for anti-DDP resistance in human osteosarcoma. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | prostaglandin D2 receptor | Homo sapiens |
| 6 | Conclusion: In short, NCK1-AS1 knockdown enhanced DDP sensitivity of osteosarcoma cells by regulating miR-137, which may be a novel potential target for anti-DDP resistance in human osteosarcoma. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | prostaglandin D2 receptor | Homo sapiens |