Title : Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.

Pub. Date : 2020 Aug

PMID : 31905247






1 Functional Relationships(s)
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1 Mechanistically, the disruption of Ggps1 increased the levels of hepatic FPP and its metabolite farnesol, thereby resulting in farnesoid X receptor (FXR) activation, which modulated hepatic bile acid metabolism and reduced hepatic bile acids. Farnesol nuclear receptor subfamily 1, group H, member 4 Mus musculus