Title : Molecular cloning and the involvement of IRE1α-XBP1s signaling pathway in palmitic acid induced - Inflammation in primary hepatocytes from large yellow croaker (Larimichthys crocea).

Pub. Date : 2020 Mar

PMID : 31904542






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The ER stress-inducing agent tunicamycin (Tm) and PA treatment significantly activated the IRE1alpha-XBP1s signaling pathway and increased the pro-inflammatory genes expression including tumor necrosis factor alpha (tnfalpha), interleukin 6 (il-6) and interleukin 1beta (il-1beta) (P < 0.05). Tunicamycin LOW QUALITY PROTEIN: X-box-binding protein 1 Larimichthys crocea
2 The ER stress-inducing agent tunicamycin (Tm) and PA treatment significantly activated the IRE1alpha-XBP1s signaling pathway and increased the pro-inflammatory genes expression including tumor necrosis factor alpha (tnfalpha), interleukin 6 (il-6) and interleukin 1beta (il-1beta) (P < 0.05). Tunicamycin LOW QUALITY PROTEIN: X-box-binding protein 1 Larimichthys crocea
3 When KIRA6, the IRE1alpha kinase inhibitor, was used to block the IRE1alpha-XBP1s signaling pathway, the Tm and PA-induced pro-inflammatory genes expression was significantly suppressed (P < 0.05). Tunicamycin LOW QUALITY PROTEIN: X-box-binding protein 1 Larimichthys crocea